JCRB0112.1 THP-1
細胞情報
Important Notice(s)THP-1細胞の登録番号JCRB0112, JCRB0112.1の違い / Difference in JCRB0112 and JCRB0112.1
THP-1 (JCRB0112.1): When you start culture/培養開始時のお願い
細胞種類:一般細胞 (細胞分譲手数料はこちら)
細胞番号(JCRB) | JCRB0112.1 | 細胞名 | THP-1 |
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生物種(日本語) | ヒト | 組織名(日本語) | 血球・リンパ系 |
コメント(日本語) | 白血病, 急性単球性 | プロフィール | Human acute monocytic leukemia. |
別名 | THP-1/ATCC | 動物名 | human |
系統名 | 学名・属名 | Homo | |
学名・種小名 | sapiens | 性別 | M |
年齢・月齢 | young | 細胞識別情報 | available |
(癌)原発組織名 | hemo-lymphocytic | 病歴情報 | acute monocytic leukemia |
転移の有無(Y/N) | No | (癌)転移組織名 | |
遺伝的性質 | Fc,C3b receptor.HLA-A2,-A9,-B5,-DRW1,-DRW2 (original description for THP-1 by developer in 1980). | 細胞寿命 | infinite |
クライシスPDL | 形態 | lymphocyte-like | |
一般性状 | No immuno globulin productions. | 細胞分類 | tumor |
細胞樹立者名 | Tsuchiya,S. | 細胞寄託者 | Tsuchiya,S. |
分譲時制限 | Regulation not applied. | コメント | HLA-DR, My7, My9, OKM1 positive. Nonspecific peroxidase positive, peroxidase negative, a-naftol ASD chloroacetate esterase negative. by Dr. Tsuchiya. |
入手年 | 1987 | 培養培地 | RPMI1640 medium with 5% fetal calf serum. |
継代方法 | Dilution, twice a week. | 継代時細胞数 | 2-5x10^5 cells/ml |
人種 | Japanese | 炭酸ガス濃度 | 5 % |
採取組織名 | peripheral blood | 組織型 |
ウイルスDNA・RNA検出検査 (Detection of virus genome fragment by Real-time PCR) | |||||||||
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ウイルスDNA 検出検査 |
tested | ウイルスRNA 検出検査 |
tested | ||||||
CMV | - | parvoB19 | - | HCV | - | HTLV-1 | - | ||
EBV | - | HBV | - | HIV-1 | - | HTLV-2 | - | ||
HHV6 | - | HTLV-1 | - | HIV-2 | - | HAV | - | ||
HHV7 | - | HTLV-2 | - |
-/negative. +/positive. nt/not tested. (positive (+) does not immediately mean the production of infectious viral particles.) |
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BKV | - | HIV-1 | - | ||||||
JCV | - | HIV-2 | - | ||||||
ADV | - | HPV18 | - | ||||||
Notes |
Reference | |
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Pubmed id:35373342 | THP-1 reference data: proposal of an in vitro branched evolution model for cancer cell lines. Kasai F,Hirayama N,Fukushima M,Kohara A,Nakamura Y Int J Cancer. 2022 Apr 3;(): |
Pubmed id:2964957 | Regulation of Fc epsilon receptor expression on a human monoblast cell line U937. Mayumi M,Kawabe T,Kim KM,Heike T,Katamura K,Yodoi J,Mikawa H Clin Exp Immunol. 1988 Jan;71(1):202-6 |
Pubmed id:3100613 | Lymphotoxin: induction of terminal differentiation of the human myeloid leukemia cell lines HL-60 and THP-1. Hemmi H,Nakamura T,Tamura K,Shimizu Y,Kato S,Miki T,Takahashi N,Muramatsu M,Numao N,Sugamura K J Immunol. 1987 Feb 1;138(3):664-6 |
Pubmed id:2989063 | Induction of functional differentiation of a human monocytic leukemia cell line (THP-1) by retinoic acid and cholera toxin. Hemmi H,Breitman TR Jpn J Cancer Res. 1985 May;76(5):345-51 |
Pubmed id:3855620 | Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase. Tajima S,Hayashi R,Tsuchiya S,Miyake Y,Yamamoto A Biochem Biophys Res Commun. 1985 Jan 16;126(1):526-31 |
Pubmed id:6091813 | Lineage infidelity of a human myelogenous leukemia cell line. Palumbo A,Minowada J,Erikson J,Croce CM,Rovera G Blood. 1984 Nov;64(5):1059-63 |
Pubmed id:6949641 | Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Tsuchiya S,Kobayashi Y,Goto Y,Okumura H,Nakae S,Konno T,Tada K Cancer Res. 1982 Apr;42(4):1530-6 |
Pubmed id:6970727 | Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Tsuchiya S,Yamabe M,Yamaguchi Y,Kobayashi Y,Konno T,Tada K Int J Cancer. 1980 Aug;26(2):171-6 |
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